diagnostic reagents and vaccines for bacterial diseases. The division conducts basic and applied research on animal tuberculosis, swine bacterial respiratory diseases, animal mycoplasma diseases, bacterial drug resistance and waterfowl bacterial diseases. The division has developed bacteria ghost vaccines and multi-component subunit vaccines for Actinobacillus pleuropneumoniae and poultry Salmonella repectively. The division has sequenced the whole genome of a unique strain of bovine mycoplasma for the first time and discovered a number of important functional genes;  analyzed the crystal structure of Mycobacterium tuberculosis Rv0045c lipase which will lay a solid foundation for the development of new anti-tuberculosis drugs; established the gene knockout technology platform for gram-positive and negative bacteria;  developed an attenuated vaccine for poultry Salmonella enteritidis; and discovered that mycobacterium complex can spread between human and animals based on the study of  Mycobacterium bovis pathogen ecology and epidemiology.